Lymph Node Ratio as a Predictive Factor of Persistent/Recurrent Disease in Patients With Medullary Thyroid Cancer: A Single-Center Retrospective Study
Main finding · Persistent/recurrent diseaseResult — go to the resultOdds ratio 32.3 95% CI 9.8–106.4Authors' conclusion
LNR is a reliable prognostic factor to predict the risk of recurrence, persistence, and distant metastases in patients with MTC.
Study context
- Population
- Patients with medullary thyroid cancer (MTC) treated with total thyroidectomy and neck dissection
- Participants
- 95 patients
- Exposure
- Lymph node ratio (LNR) ≥0.12 vs LNR <0.12
- Outcome
- Persistent/recurrent disease
Methodological detailssingle-centre, consecutive cohort, ROC curve analysis to identify the LNR cut-off
- Single-centre
- Consecutive cohort
- ROC curve analysis to identify the LNR cut-off
Main finding
As reported in the abstract
Odds ratio
32.3
95% CI 9.8–106.4
P < 0.001
By group
LNR ≥0.12vs LNR <0.12
OR 32.3 (95% CI 9.8–106.4); P < 0.001
- LNR independently associated with persistent/recurrent disease at multivariate analysis; cut-off 0.12, AUC
- 0.85
Observational data: associations, not effects.
Further findings
| Outcome | LNR ≥0.12 | LNR <0.12 | Estimate | P value | |
|---|---|---|---|---|---|
| Distant metastasis | 34.5% | 3.0% | OR 16.8 (95% CI 3.4–83.6) | P < 0.001 | |
| Time to progression | median 15 months | median not reached | HR 7.18 (95% CI 3.01–17.11) | P < 0.001 | |
| 0.050.21520Ratio (log scale) |
Associations of LNR
- LNR positively associated with tumor size, pre- and postoperative calcitonin, postsurgery carcinoembryonic antigen, persistent/recurrent disease and distant metastases during follow-up
Original publication
Lymph Node Ratio as a Predictive Factor of Persistent/Recurrent Disease in Patients With Medullary Thyroid Cancer: A Single-Center Retrospective Study. Endocr Pract. Published 25 November 2023. doi:10.
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