Effect of Thyroid-Stimulating Hormone Suppression Therapy on Cardiac Structure and Function in Patients With Differentiated Thyroid Cancer After Thyroidectomy: A Systematic Review and Meta-Analysis
Authors' conclusion
Long-term TSH suppression therapy leads to cardiac hypertrophy and impaired cardiac diastolic function in patients with DTC. These changes may be related to the duration of TSH suppression therapy. Large prospective studies with long follow-up periods are needed to validate these findings.
Study context
- Population
- Patients with differentiated thyroid cancer (DTC) following thyroidectomy13 studies
- Comparison
- Long-term thyroid-stimulating hormone (TSH) suppression therapy after thyroidectomy vs healthy controls
- Outcome
- Cardiac structure and function (13 outcomes: cardiac morphology, systolic and diastolic function)
Methodological detailsfixed or random effects models, standard mean differences, PubMed, Embase, Cochrane Library and Web of Science searched from inception to January 6, 2023, no language restrictions
- Fixed or random effects models
- Standard mean differences
- PubMed, Embase, Cochrane Library and Web of Science searched from inception to January 6, 2023, no language restrictions
Pooled result
As reported in the abstract
- Left ventricular mass index, posterior wall thickness, interventricular septal thickness and isovolumic relaxation time increased vs healthy controls
- E/A velocity ratio and E-wave velocity decreased vs healthy controls
- Left ventricular ejection fraction and cardiac output did not change
Further pooled results
- Interventricular septal thickness significantly correlated with duration of TSH suppression therapy
Original publication
Effect of Thyroid-Stimulating Hormone Suppression Therapy on Cardiac Structure and Function in Patients With Differentiated Thyroid Cancer After Thyroidectomy: A Systematic Review and Meta-Analysis. Endocr Pract. Published 24 November 2023. doi:10.
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