New Findings on Presentation and Outcome of Patients With Adrenocortical Cancer: Results From a National Cohort Study
An erratum to this article was published (J Clin Endocrinol Metab, 19 Apr 2024 ↗)
Authors' conclusion
Our study shows that ACC is a sex-related disease and demonstrates that an incidental presentation is associated with a better outcome. Given the correlation between RFS and OS, RFS may be used as a surrogate endpoint in clinical studies.
Study context
- Population
- Patients with adrenocortical cancer (ACC) diagnosed in 12 referral centers in Italy, January 1990 to June 2018
- Participants
- 512 patients
- Outcome
- Presentation, treatment and prognostic factors
Methodological detailsnationwide, multicentre (12 referral centers)
- Nationwide
- Multicentre (12 referral centers)
Main finding
As reported in the abstract
- ACC diagnosed as incidentalomas
- 38.1%
- Women
- 60.2%
- Open surgical approach
- 72%
- Adjuvant mitotane after resection
- 62.7%
- Recurrence after tumor resection
- 56.2%
- Death
- 38.1%
Observational data: associations, not effects.
Original publication
New Findings on Presentation and Outcome of Patients With Adrenocortical Cancer: Results From a National Cohort Study. J Clin Endocrinol Metab. Published 6 April 2023. doi:10.
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