A Comprehensive Study on the Diagnosis and Management of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features
Study context
- Population
- Patients diagnosed with NIFTP at resection, 2016–2022; 6.6% of thyroid surgeries183 NIFTP-only
- Participants
- 319 patients
- Exposure
- Total thyroidectomy vs hemithyroidectomy in NIFTP-only
- Outcome
- Clinical, cytological, molecular and imaging features of NIFTP
Methodological detailssingle-institution
- Single-institution
Main finding
As reported in the abstract
- Female:male ratio
- 2.7:1
- Mean age
- 52 years
- Median NIFTP size
- 2.1 cm
- Multiple nodules
- 23% (n = 73)
- Multifocal NIFTP
- 12% (n = 39)
- Fine needle aspiration (FNA) (n = 255): nondiagnostic
- 5%
- FNA: benign
- 13%
- FNA: AUS/FLUS
- 49%
- FNA: FN/SFN
- 17%
- FNA: suspicious for malignancy
- 12%
- FNA: malignant
- 4%
- Molecular alterations (RAS or RAS-like)
- 93% (n = 114)
- Thyroid Imaging Reporting and Data System (TI-RADS) 4
- 50%
- TI-RADS 3
- 26%
- TI-RADS 5
- 20%
Observational data: associations, not effects.
Further findings
Extent of surgery in NIFTP-only (n = 183)
Extent of surgery in NIFTP-only (n = 183)
- Univariate: Total thyroidectomy (TT) patients had higher Bethesda category by FNA, more often aberrant preoperative thyroid function, and/or FNA of additional nodule(s)
- Multivariable: Bethesda V NIFTP, with other nodules evaluated by FNA and aberrant preoperative thyroid function, independently predicts TT
- Bethesda II NIFTP correlated significantly with hemithyroidectomy (HT)
Postoperative management and outcome, NIFTP-only · median follow-up 35 months (6-76 months; n = 120)
- ≥1 postoperative surveillance US
- 52 (28%)
- HT patients with completion thyroidectomy or postoperative RAI
- 0
- Recurrence or metastases
- 0
Original publication
A Comprehensive Study on the Diagnosis and Management of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features. Thyroid. Published 30 March 2023. doi:10.
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