Gestational diabetes & diabetes in pregnancy
Lack of Validity of the Glucose Management Indicator in Type 1 Diabetes in Pregnancy
Authors' conclusion
GMI is not an accurate replacement for HbA1c in pregnancy in women with type 1 diabetes.
Study context
- Population
- Women with T1D in pregnancy from CONCEPTT; HbA1c, continuous glucose monitoring (CGM) metrics and glucose management indicator (GMI) at 12, 24 and 34 weeks' gestation
- Participants
- 220 women
- Comparison
- GMI vs HbA1c and CGM metrics
- Primary endpoint
- Accuracy of GMI and associations with pregnancy outcomes
- Follow-up
- 12, 24, and 34 weeks' gestation
Methodological detailsLogistic/linear regression and Bland-Altman plots
- Logistic/linear regression and Bland-Altman plots
Primary result
As reported in the abstract
- GMI equations performed less accurately in pregnancy, with higher bias, especially in first and third trimesters
- GMI and mean CGM glucose had equivalent predictive capability over pregnancy outcomes
- GMI offered no additional predictive capability over TIR (63-140 mg/dL; 3.5-7.8 mmol/L), TAR (>140 mg/dL; >7.8 mmol/L) and average CGM glucose
Original publication
Lack of Validity of the Glucose Management Indicator in Type 1 Diabetes in Pregnancy. Diabetes Care. Published 2 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →