Kidney Hyperfiltration and Mitochondrial Changes Are Associated With Estimated Glomerular Filtration Rate (eGFR) Decline in Young People With Type 1 Diabetes
Authors' conclusion
Hyperfiltration during adolescence is significantly associated with greater reduction in eGFR and higher risk of rapid eGFR decline after ∼9 years, following transition into young adulthood in type 1 diabetes. Urinary mtDNA:nDNA measured during adolescence may be a novel predictor of early changes in kidney function.
Study context
- Population
- Adolescents with T1D (mean [SD] age 14.2 [1.5] years; mean diabetes duration 6.7 [3.0] years), followed up 9.2 (1.3) years later
- Participants
- 80 adolescents
- Exposure
- Hyperfiltration vs no hyperfiltration at baseline in adolescence
- Outcome
- Annual change in eGFR from adolescence to follow-up
- Follow-up
- 9.2 (1.3) years
Main finding
As reported in the abstract
Annual rate of eGFR change
Hyperfiltration
−1.46
SD 3.07 · mL/min/1.73 m²/year
Non-hyperfiltration
−0.51
SD 2.48 · mL/min/1.73 m²/year
P = 0.02
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Rapid eGFR decline (>3 mL/min/1.73 m²/year) | 14.11 (2.30–86.60) | P = 0.004 | |
| 0.050.21520Odds ratio (log scale) |
Hyperfiltration prevalence at baseline
- Adolescents with hyperfiltration (>135 mL/min/1.73 m²)
- 31%
Diabetic kidney disease · follow-up
- Participants with diabetic kidney disease
- 4.2%
Baseline urinary mtDNA:nDNA and eGFR decline
- Significantly associated with greater annual eGFR decline and rapid eGFR decline in univariable but not multivariable modeling
Original publication
Kidney Hyperfiltration and Mitochondrial Changes Are Associated With eGFR Decline in Young People With Type 1 Diabetes. J Clin Endocrinol Metab. Published 11 November 2024. doi:10.
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