Lipids & metabolic liver disease
Joint associations of anthropometric indices and C-reactive protein-triglyceride-glucose index with incident hypertension: a stratified analysis by blood pressure level from the China Health and Retirement Longitudinal Study (CHARLS), 2011–2020
Authors' conclusion
These anthropometric indices and CTI effectively predicted hypertension risk across populations with different baseline blood pressures, both independently and in combination. Among all evaluations, the combination of BRI and CTI emerged as the optimal approach, most robustly associated with incident hypertension and providing the greatest improvement in risk discrimination and reclassification.
Study context
- Population
- Participants of the China Health and Retirement Longitudinal Study (CHARLS), 2011–2020 waves; median age 56 years, 46.04% male
- Participants
- 4,735 participants
- Exposure
- Higher vs lower anthropometric indices and CTI, jointly
- Outcome
- Incident hypertension
- Follow-up
- 9-year follow-up
Methodological detailsstratified analysis by baseline blood pressure, multivariable Cox regression, restricted cubic spline, mediation and interaction analyses
- Stratified analysis by baseline blood pressure
- Multivariable Cox regression
- Restricted cubic spline
- Mediation and interaction analyses
Main finding
As reported in the abstract
Both BRI and CTI above median vs Lower levels of bothHazard ratio (95% CI)
Total population
1.51(1.33–1.71)
Normal BP
1.58(1.29–1.93)
Elevated BP
1.45(1.23–1.71)
- Developed hypertension (whole cohort)
- 1,852 (39.37%)
Observational data: associations, not effects.
Further findings
Predictive performance
- AUC, integrated BRI + CTI model (best)
- 0.747
- Adding anthropometric indices and CTI to basic model significantly improved prediction
Mediation
- CTI significantly mediated the association between anthropometric indices and hypertension
Original publication
Joint associations of anthropometric indices and C-reactive protein-triglyceride-glucose index with incident hypertension: a stratified analysis by blood pressure level from the CHARLS, 2011–2020. Cardiovasc Diabetol. Published 23 March 2026. doi:10.
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