Lipids & metabolic liver disease
Association between the combined c-reactive protein-triglyceride glucose index and hypertension with long-term stroke among cardiovascular-kidney-metabolic syndrome stages 0–3 population: a nationwide prospective cohort study
Main finding · StrokeResult — go to the resultFully adjusted HR 3.19 95% CI 2.62–3.88Authors' conclusion
Integrating CTI with hypertension significantly improves stroke risk stratification in CKM stage 0-3 populations, supporting its potential for early identification of high-risk individuals.
Study context
- Population
- Cardiovascular-kidney-metabolic syndrome stages 0–3 population, China Health and Retirement Longitudinal Study (CHARLS)
- Participants
- 9,082 participants
- Exposure
- Highest vs lowest combined CTI-hypertension group
- Outcome
- Incident stroke
- Follow-up
- median 9-year follow-up
Methodological detailsnationwide, longitudinal
- Nationwide
- Longitudinal
Main finding
Stroke
Fully adjusted HR
3.19
95% CI 2.62–3.88
Highest CTI-hypertensionvs Lowest CTI-hypertension
fully adjusted HR 3.19 (95% CI 2.62–3.88)
As reported in the abstract
- Incident stroke cases
- 811 (8.9%)
Observational data: associations, not effects.
Further findings
Predictive performance for stroke (AUC)
- Combined CTI-hypertension model AUC
- 0.672
- Hypertension-alone model AUC
- 0.661
- CTI-alone model AUC
- 0.651
Weighted Quantile Sum (WQS) contribution of components
- C-reactive protein
- 38.8%
- Hypertension
- 31.7%
Original publication
Association between the combined c-reactive protein-triglyceride glucose index and hypertension with long-term stroke among cardiovascular-kidney-metabolic syndrome stages 0–3 population: a nationwide prospective cohort study. Cardiovasc Diabetol. Published 24 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →