Iodinated Contrast Administration and Risks of Thyroid Dysfunction: A Retrospective Cohort Analysis of the U.S. Veterans Health Administration System
Main finding · Thyroid dysfunctionResult — go to the resultOdds ratio 1.39 95% CI 1.37–1.41Authors' conclusion
In this largest analysis of U.S. adults to date, iodine exposure was associated with only clinically small absolute increased risks of thyroid dysfunction, particularly in men.
Study context
- Population
- US veterans aged ≥18 years with a serum TSH measurement, Veterans Health Administration database 1998–2021; mean age 63.5 years, 92.9% men, 65.6% non-Hispanic White
- Participants
- 4,253,119 veterans8,729,155 TSH pairs
- Exposure
- Iodinated contrast exposure vs no iodine exposure
- Iodine contrastn = 499,897
- Outcome
- Incident thyroid dysfunction (defined by repeated measurements of serum thyroid function) following iodine exposure
Methodological detailsmultivariable logistic regression adjusted for age, sex, race/ethnicity, baseline TSH and interval between TSH measurements
- Multivariable logistic regression adjusted for age, sex, race/ethnicity, baseline TSH and interval between TSH measurements
Main finding
Thyroid dysfunction
Odds ratio
1.39
95% CI 1.37–1.41
P < 0.001
By group
Iodine contrastvs No iodine exposure
OR 1.39 (95% CI 1.37–1.41); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Thyroid dysfunction by sex
- Men: OR for thyroid dysfunction after iodine exposure
- OR = 1.42, 95% CI = 1.40-1.44
- Women: OR for thyroid dysfunction after iodine exposure
- OR = 1.16, 95% CI = 1.11-1.21
- Men at higher risk of thyroid dysfunction than women
- P for interaction < 0.001
Types of thyroid dysfunction
- Increased risk consistent for all types of thyroid dysfunction (overt or subclinical hypo-/hyperthyroidism)
Original publication
Iodinated Contrast Administration and Risks of Thyroid Dysfunction: A Retrospective Cohort Analysis of the U.S. Veterans Health Administration System. Thyroid. Published 25 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →