Cardiac Electrical and Structural Changes after Iodinated Contrast Media Administration: A Longitudinal Cohort Analysis
Main finding · Follow-up EF, adjusted for baseline valuesResult — go to the resultDifference −4.23 % CI −7.66% to −0.79%Authors' conclusion
Over a period of up to 36 months, a larger amount of administered iodine contrast was associated with lower EF among participants.
Study context
- Population
- Patients receiving iodine contrast for elective CT or coronary angiography; median age 70 years, 98% male
- Participants
- 129 patients
- Exposure
- High-iodine contrast vs low-iodine contrast
- Outcome
- Changes in cardiac electrophysiology (EKG) and structure (echocardiography) by amount of iodinated contrast
- Follow-up
- Until 36 months
Methodological detailsprospectively enrolled, serial follow-up until 36 months, mixed effect models
- Prospectively enrolled
- Serial follow-up until 36 months
- Mixed effect models
Main finding
Follow-up EF, adjusted for baseline values · up to 36 months
Difference
−4.23 %
CI −7.66% to −0.79%
High-iodine contrastvs Low-iodine contrast
difference −4.23 % (CI −7.66% to −0.79%)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Dose-response analyses
- Lower ejection fraction (EF) with larger amounts of iodine received; trends not significant for EKG parameters
Original publication
Cardiac Electrical and Structural Changes after Iodinated Contrast Media Administration: A Longitudinal Cohort Analysis. Thyroid. Published 27 August 2024. doi:10.
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