Hypothyroidism in Infants after Enteral Administration of Iodinated Contrast Media: A Rare but Serious Complication
Authors' conclusion
In this study, 1 patient developed primary hypothyroidism requiring levothyroxine treatment after enteral ICM administration. We recommend monitoring of thyroid function in infants younger than 6 months after enteral ICM administration, especially in preterm born infants.
Study context
- Population
- Infants <6 months of age undergoing radiological examination (mostly AXR) with enteral iodinated contrast medium (ICM), November 2022–July 202451.5% preterm
- Participants
- 33 infants
- Outcome
- Occurrence of hypothyroidism after enteral ICM administration (TSH and FT4 measured around days 5 and 10, repeated on day 15 if abnormal)
Main finding
As reported in the abstract
during follow-up
- Abnormal thyroid-stimulating hormone (TSH) or FT4 levels (all male)
- 5 (15.2%)
- ICM-induced hypothyroidism requiring treatment
- 1
- Physiological escape of the Wolff-Chaikoff effect
- 2
- Non-thyroidal illness/hypothyroxinemia of prematurity
- 2
- Born preterm among those with abnormal TSH or FT4
- 4 of 5
Observational data: associations, not effects.
Further findings
Stasis of ICM after 2 days · day 2
- Stasis of ICM
- 12 of 28 (42.9%)
Original publication
Hypothyroidism in Infants after Enteral Administration of Iodinated Contrast Media: A Rare but Serious Complication. Horm Res Paediatr. Published 13 February 2025. doi:10.
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