Long-Term Impact of Thyroid Eye Disease on Quality of Life: Insights From a Retrospective Cohort Study
Authors' conclusion
Our data reveal that disease severity, the timing of interventions and disease progression contribute to less favorable long-term QoL outcomes, extending years beyond active treatment. Early and accurate diagnosis and appropriate treatment can minimize poor long-term QoL in patients with TED.
Study context
- Population
- Patients treated for active, moderate-to-severe and severe thyroid eye disease (TED); mean follow-up 8 years
- Participants
- 151 patients
- Outcome
- Long-term QoL and factors influencing it, incl. effects of previous TED treatments
- Follow-up
- Mean 8 years
Main finding
As reported in the abstract
Factors associated with long-term QoL
- Higher clinical activity scores at diagnosis correlated with lower quality of life (QoL) scores
- Thyroidectomy before immunosuppressive treatment associated with lower QoL and increased likelihood of orbital decompression
- Disease progression necessitating second-line treatments negatively affected QoL
- Decrease in TRAb during active treatment and early treatment initiation positively affected visual functioning
- No significant trend in QoL changes over time (time-dependent regression)
Observational data: associations, not effects.
Original publication
Long-Term Impact of Thyroid Eye Disease on Quality of Life: Insights From a Retrospective Cohort Study. Endocr Pract. Published 11 February 2025. doi:10.
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