The Association Between Thyrotropin and Clinically Relevant Depression: A Retrospective Cross-Sectional Study
Authors' conclusion
Thyroid dysfunction is associated with an increase in the odds of depression.
Study context
- Population
- Consecutive adults (≥18 years) with TSH and Patient Health Questionnaire (PHQ-9) within 6 months of index visit, October 2016–May 2021, University of Utah Health; mean age 42.41 ± 16.10 years, 69.10% females, 45.23% with mood disorders
- Participants
- 33,138 adults
- Exposure
- TSH level and clinically relevant depression
- Outcome
- Clinically relevant depression (CRD), defined as PHQ-9 ≥ 10
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
CRD per TSH level (adjusted for age, sex, BMI, Charlson Comorbidity Index, thyroid hormone replacement (THR) and antidepressant (AD) use)
Odds ratio (CI)P value
TSH level
1.01(1.01–1.02)
P < 0.009Low TSH
1.19(1.04–1.37)
High TSH
1.26(1.13–1.40)
Per TSH level, as printed
Observational data: associations, not effects.
Further findings
Prevalence of clinically relevant depression (CRD)
- Patients with CRD
- 49.70%
Original publication
The Association Between Thyrotropin and Clinically Relevant Depression: A Retrospective Cross-Sectional Study. Thyroid. Published 5 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →