Effects of iodine contrast media on thyroid function – a prospective study
Authors' conclusion
The results of this prospective study support the notion that in iodine-sufficient countries, ICM-associated thyroid dysfunction is rare, usually mild, self-limiting and oligo/asymptomatic in subjects aged 50-65 years.
Study context
- Population
- Randomly selected individuals aged 50–65 years undergoing contrast-enhanced coronary CT angiography (CCTA) with iodine contrast medium (ICM) in SCAPIS, Sweden368 with ThyPRO
- Participants
- 422 participants
- Outcome
- Incidence, magnitude and clinical impact of contrast-induced thyroid dysfunction
- Follow-up
- 4-12 weeks after CCTA
Methodological detailswithin SCAPIS
- Within SCAPIS
Main finding
As reported in the abstract
Thyroid dysfunction after ICM
Overt hypo- or hyperthyroidism after ICM
0
Subclinical hypo- or hyperthyroidism or isolated low/high free thyroxine (fT4) in those with normal pre-CCTA levels
3.5%
Observational data: associations, not effects.
Further findings
Thyroid-related symptoms (ThyPRO)
- No increased thyroid-related symptoms in those developing dysfunction vs remaining cohort
Risk factors for subclinical hypothyroidism
- Elevated TPOAb and being born outside Sweden were risk factors
- Thyroid nodules not associated with ICM-induced thyroid dysfunction
Original publication
Effects of iodine contrast media on thyroid function – a prospective study. Eur Thyroid J. Published 11 November 2024. doi:10.
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