Graves’ hyperthyroidism treated with potassium iodide: early response and after 2 years of follow-up
Authors' conclusion
KI therapy was useful in the treatment of GD. A sufficient dose of KI was effective in >50% of GD patients from 4 weeks to 2 years, and 42.7% (76.5% of 'KI-effective' patients at 4 weeks) remained 'KI-effective' throughout the 2 years.
Study context
- Population
- Untreated patients with Graves' hyperthyroidism (GD)288 followed 2 years
- Participants
- 324 patients
- Outcome
- Outcome over 2 years among patients followed for 2 years
- Follow-up
- 2 years
Methodological detailssingle-group, 2-year follow-up
- Single-group
- 2-year follow-up
Main finding
As reported in the abstract
Remained KI-effective (KI or KI + levothyroxine (LT4)) throughout 2 years (KI Group)
42.7%
Well-controlled with additional MMI for 1-24 months
30.9%
Successfully treated with ablative therapy (mainly radioactive iodine (RI))
26.4%
Observational data: associations, not effects.
Further findings
Early response to KI · 2-4 weeks
- Serum thyroid hormone levels decreased at 2 weeks
- all 324 patients
- fT4 normal or low at 4 weeks
- 74.7%
- fT3 normal or low at 4 weeks
- 50.6%
- Both fT4 and fT3 normal or low at 4 weeks
- 50.6%
GD well-controlled with KI or KI + LT4 (cross-sectional survey) · all time points over 2 years
- KI-effective
- >50% of patients
KI Group among KI-effective patients at 4 weeks · 2 years
- Classified into KI Group
- 76.5%
Safety
- Patients with adverse effects from KI
- 0
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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