Echogenicity as a standalone nodule characteristic is not inferior to the TN image reporting and data systems (TIRADS) systems in the 10–20 mm nodule diameter range in patient selection for fine needle aspiration: a pilot study
Authors' conclusion
In contrast to >20 mm diameter nodules, the recommendation of FNA may rely on a single US feature, echogenicity, in the 10-20 mm size range. If independently confirmed in larger cohorts, this may simplify nodule evaluation in this size range.
Study context
- Population
- Histologically verified thyroid nodules evaluated on ultrasound (US) video recordings for fine needle aspiration (FNA) selection; nodules ≥10 mm110 nodules ≥10 mm analysed
- Participants
- 123 participants
- Comparison
- Echogenicity alone vs five TIRADS systems
- Outcome
- Sensitivity and specificity for identifying malignant nodules (indication for FNA)
Methodological detailspilot study, online video evaluation by seven experienced investigators, four countries, histologically verified nodules
- Pilot study
- Online video evaluation by seven experienced investigators
- Four countries
- Histologically verified nodules
Performance
As reported in the abstract
Identification of malignant nodules, 10-20 mm size range
| Test or model | Sensitivity | Specificity |
|---|---|---|
| TIRADS | 80.5-91.0% | 31.4-50.9% |
| Echogenicity | 87.5% | 43.4% |
Sensitivity
TIRADS80.5-91.0%
Echogenicity87.5%
Specificity
TIRADS31.4-50.9%
Echogenicity43.4%
Further findings
10-20 mm vs >20 mm
Proportion of cancers that were hypoechoic: 10-20 mm vs >20 mm nodules
P = 0.05
Isoechoic vs Hypoechoic
Proportion of nodules with suspicious findings, 10-20 mm: hypoechoic vs isoechoic · significantly lower with isoechoic
P < 0.05
Original publication
Echogenicity as a standalone nodule characteristic is not inferior to the TIRADS systems in the 10–20 mm nodule diameter range in patient selection for fine needle aspiration: a pilot study. Eur Thyroid J. Published 6 November 2024. doi:10.
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