Effect of Antithyroid Drugs Treatment Duration on The Remission Rates of Graves' Disease in Children and Adolescents: A Single‐Arm Meta‐Analysis and Systematic Review
Authors' conclusion
The overall RR for the treatment of paediatric GD with ATDs is 25.4%, and prolonging the treatment course can indeed lead to an increased RR.
Study context
- Population
- Children and adolescents with Graves' disease (GD) treated with antithyroid drugs (ATDs) (2600 girls, 759 boys); databases searched to 23 November 2023
- Participants
- 3,359 children19 studies
- Comparison
- ATD treatment duration
- Outcome
- RR
Methodological detailsmeta-regression, subgroup comparisons
- Meta-regression
- Subgroup comparisons
Pooled result
As reported in the abstract
Overall remission rate with ATDs
Pooled overall remission rate
25.4%
95% CI 20.7%, 30.1%
Further pooled results
Remission rate by ATD treatment duration
Meta-regression: remission rate per additional year of ATD treatment
- Increase in remission rate per additional year
- 3.8% (Coefficient; 95% CI 0.6%, 7.0%; p < 0.01)
- Treatment duration and follow-up duration were significant sources of high heterogeneity
Original publication
Effect of Antithyroid Drugs Treatment Duration on The Remission Rates of Graves' Disease in Children and Adolescents: A Single‐Arm Meta‐Analysis and Systematic Review. Clin Endocrinol (Oxf). Published 5 November 2024. doi:10.
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