Female Reproductive System and Thyroid Dysfunction: Findings from a 12-Year Follow-Up in the Tehran Thyroid Study
Authors' conclusion
Our results suggest that the female reproductive system may be associated with thyroid function. Parity and abortion are associated with the occurrence of TD.
Study context
- Population
- Women from the Tehran Thyroid Study2,191 euthyroid followed up
- Participants
- 2,711 women
- Exposure
- Parity, abortion and menopause status vs thyroid dysfunction
- Outcome
- Prevalence and incidence of thyroid dysfunction by parity, abortion and menopause status
Methodological detailsTehran Thyroid Study, cross-sectional analysis at baseline, survival analysis with follow-up in 3-year intervals, multinomial logistic regression, multivariable Cox proportional hazard model, adjusted for age, smoking, BMI and TPOAb positivity
- Tehran Thyroid Study
- Cross-sectional analysis at baseline
- Survival analysis with follow-up in 3-year intervals
- Multinomial logistic regression
- Multivariable Cox proportional hazard model
- Adjusted for age, smoking, BMI and TPOAb positivity
Main finding
As reported in the abstract
Prevalent TD at baseline
Multiple parities (≥4) and overt hypothyroidism, OR
1.12
CI 1.0–1.26
Multiple parities (≥4) and subclinical hyperthyroidism, OR
1.11
CI 1.03–1.21
Multiple abortions and overt hyperthyroidism, OR
2.09
CI 1.02–4.26
Observational data: associations, not effects.
Further findings
Incident thyroid dysfunction (TD) · over follow-up
- Multiple parities significantly associated with incident subclinical and clinical hypothyroidism
- History of abortion associated with reduced risk of incident overt hypothyroidism
Menopause status
- No significant association with prevalence or incidence of hypo- or hyperthyroidism
Original publication
Female Reproductive System and Thyroid Dysfunction: Findings from a 12-Year Follow-Up in the Tehran Thyroid Study. Thyroid. Published 28 October 2024. doi:10.
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