Cost-effectiveness Analysis Comparing Conventional and Digital Software Supported Management for Hypothyroidism
Authors' conclusion
The incorporation of the digital monitoring solution has demonstrated positive cost-effectiveness in hypothyroidism management when compared to the standard care. The cost of the digital monitoring solution and its sensitivity are key factors in determining cost-effectiveness. Striking a balance among the cost of digital monitoring support, the precision of hormonal level monitoring, and its effectiveness for the specific group of hypothyroid patients in real-world clinical practice is essential.
Study context
- Population
- Simulated cohort of 40-year-old patients with hypothyroidismsimulated cohort
- Participants
- 10,000 participants
- Exposure
- Wearable/mobile-based digital thyroid function monitoring vs conventional management
- Outcome
- ICER (cost per QALY gained)
- Follow-up
- Lifetime
Methodological detailsdecision-analytic Markov state-transition simulation model, simulated cohort, health care sector perspective, 4.5% annual discount rate, costs adjusted to 2022 levels, lifetime horizon, deterministic and probabilistic sensitivity analyses
- Decision-analytic Markov state-transition simulation model
- Simulated cohort
- Health care sector perspective
- 4.5% annual discount rate
- Costs adjusted to 2022 levels
- Lifetime horizon
- Deterministic and probabilistic sensitivity analyses
Main finding
As reported in the abstract
Incremental quality-adjusted life-years (QALYs)
0.65 QALYs
Digital monitoring
Incremental cost
$11 700.87
Digital monitoring
ICER
$17 988.97 per QALY gained
Digital monitoring
Observational data: associations, not effects.
Further findings
Probabilistic sensitivity analysis
- Digital-powered software optimal strategy at WTP threshold of $32 255/QALY gained
- 99% of iterations
- ICER most sensitive to annual cost of the digital monitoring solution
Original publication
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