Haemodynamics of hyperthyroidism: increased cardiac work and findings related to vasodilatation
Authors' conclusion
Hyperthyroid patients exhibited hyperdynamic circulation, reduced vascular resistance, reduced peripheral but not central blood pressure, and higher pulse pressure amplification. Furthermore, left cardiac workload was increased in parallel with unfavourable changes in coronary perfusion conditions.
Study context
- Population
- Hyperthyroid patients early after initiation of antithyroid medication and matched euthyroid subjects3 matched controls per patient
- Participants
- 20 vs 60
- Comparison
- Hyperthyroid patients vs euthyroid controls
- Hyperthyroidn = 20
- Euthyroidn = 60reference
- Outcome
- Non-invasive haemodynamics at rest
Methodological detailsmatched (3 controls per patient: age, sex, BMI, smoking status), non-invasive haemodynamic measurements at rest and passive head-up tilt
- Matched (3 controls per patient: age, sex, BMI, smoking status)
- Non-invasive haemodynamic measurements at rest and passive head-up tilt
Main finding
As reported in the abstract
- Lower in hyperthyroidism
- difference in finger blood pressure 16/12 mmHg; P < 0.001
- Higher in hyperthyroidism
- difference in radial pulse pressure ≈5 mmHg; P = 0.040
- Non-invasive haemodynamics at rest
- difference in systemic vascular resistance −18%; P < 0.001
- Non-invasive haemodynamics at rest
- difference in heart rate +19 beats/min; P < 0.001
- Non-invasive haemodynamics at rest
- difference in cardiac index +28%; P < 0.001
- Non-invasive haemodynamics at rest
- difference in left cardiac work +31%; P < 0.001
- Reduced in hyperthyroidism
- difference in subendocardial viability ratio 19%; P < 0.001
- Augmented pulse pressure amplification in hyperthyroidism
- P = 0.045
Observational data: associations, not effects.
Further findings
Responses to upright posture (passive head-up tilt)
- Reductions in systolic and diastolic finger BP in hyperthyroid vs euthyroid
- P < 0.001
- Higher increase in heart rate in hyperthyroid vs euthyroid
- P = 0.014
Original publication
Haemodynamics of hyperthyroidism: increased cardiac work and findings related to vasodilatation. Eur Thyroid J. Published 24 October 2024. doi:10.
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