Cardiac Autonomic Neuropathy in Graves' Disease: Smoking and Age as Predictive Factors
Authors' conclusion
The prevalence of CAN in euthyroid GD patients was 20%. Changes in the cardiac autonomic nervous system were identified, pointing to the importance of evaluating this complication in these patients. Smoking was a predictive factor for CAN, increasing its relationship with conditions that aggravate GD.
Study context
- Population
- Euthyroid patients with Graves' disease (GD) and healthy euthyroid controls
- Participants
- 60 vs 50
- Exposure
- Euthyroid GD patients vs healthy euthyroid controls
- GDn = 60
- Controln = 50reference
- Outcome
- Cardiac autonomic neuropathy (CAN) by cardiovascular reflex tests and heart rate variability
Main finding
As reported in the abstract
CAN prevalence
CAN prevalence
Incipient CAN
Established CAN
- GD vs Control: P = 0.7479
Observational data: associations, not effects.
Further findings
Deep breathing test in GD with cardiac autonomic neuropathy (CAN)
- All GD patients with CAN had an altered deep breathing test
Factors associated with CAN
- Age and smoking associated with presence of CAN
- Higher TRAb at diagnosis decreased the chance of CAN
Original publication
Cardiac Autonomic Neuropathy in Graves' Disease: Smoking and Age as Predictive Factors. Endocr Pract. Published 20 May 2024. doi:10.
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