Novel Biomarkers Reveal Mismatch Between Tissue and Serum Thyroid Hormone Status in Amiodarone-Induced Hyperthyroidism
Authors' conclusion
We developed a minimally invasive approach using HF markers to assess tissue TH economy that could complement routine diagnostics in controversial cases. We observed that a substantial proportion of patients with AIH do not develop tissue hyperthyroidism, indicating that amiodarone protects tissues from thyrotoxicosis. Assessing tissue TH action in patients with AIH may be warranted for treatment decisions.
Study context
- Population
- Amiodarone-treated patients (hypothyroid, euthyroid, hyperthyroid); Thyroid hormone action indicator (THAI) mice
- Outcome
- Tissue TH status (HF-based) vs serum-based TH status
Methodological detailsnext-generation sequencing of hair follicles, qPCR validation, classification model, THAI mouse model
- Next-generation sequencing of hair follicles
- qPCR validation
- Classification model
- THAI mouse model
Main finding
As reported in the abstract
- Classification model validated; predicted tissue TH status with good performance
- Serum- and HF-based TH statuses concordant in hypothyroid and euthyroid amiodarone-treated patients
- Amiodarone decreased coincidence of serum- and HF-based TH statuses in hyperthyroid patients; Amiodarone-induced hyperthyroidism (AIH) not unequivocally associated with tissue hyperthyroidism
- In THAI mice, amiodarone prevented tissue hyperthyroidism despite high serum free thyroxine
Original publication
Novel Biomarkers Reveal Mismatch Between Tissue and Serum Thyroid Hormone Status in Amiodarone-Induced Hyperthyroidism. J Clin Endocrinol Metab. Published 30 July 2024. doi:10.
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