Antithyroid drug treatment in pregnancy: a first report from the Danish PRETHYR multicenter study
Authors' conclusion
This is the first report from a multicenter study on pregnant women with GD and women treated with ATDs during pregnancy. The results provide insight into the current clinical treatment practices of hyperthyroidism in Denmark.
Study context
- Population
- Pregnant women with Graves' disease (GD) and women treated with antithyroid drugs (ATDs) in pregnancy, Denmark (PRETHYR)97.5% with GD
- Participants
- 121 women
- Exposure
- Women receiving ATDs in pregnancy vs women not treated with ATDs
- ATD-treatedn = 60
- Outcome
- ATD treatment in pregnancy among 102 women with known preconception thyroid disease and no prior definitive treatment
Methodological detailsData from patient questionnaires and medical record review
- Data from patient questionnaires and medical record review
Main finding
As reported in the abstract
ATD-treated
58.8%
60
Observational data: associations, not effects.
Further findings
Preconception switch of ATD · before conception
- Women on methimazole switched to propylthiouracil
- 59.1%
- Switched from propylthiouracil to methimazole
- 10.7%
Original publication
Antithyroid drug treatment in pregnancy: a first report from the Danish PRETHYR multicenter study. J Clin Endocrinol Metab. Published 6 March 2026. doi:10.
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