Contrast‐Enhanced Ultrasound for Diagnosing Thyroid Nodules With Indeterminate Cytology: A Retrospective Study
Authors' conclusion
CEUS is helpful in diagnosing thyroid nodules with indeterminate cytology. CUS combined with CEUS is highly valuable for predicting malignancy.
Study context
- Population
- Thyroid nodules with indeterminate cytology on US-guided fine needle aspiration biopsy that underwent contrast-enhanced ultrasound (CEUS), September 2019–July 2022
- Participants
- 116 nodules
- Comparison
- Conventional ultrasound (CUS) vs CEUS vs CUS combined with CEUS
- Outcome
- AUC for predicting malignancy
Methodological detailssingle-centre
- Single-centre
Performance
As reported in the abstract
| Test or model | AUC |
|---|---|
| CUS | 0.769 |
| CEUS | 0.848 |
| CUS + CEUS | 0.934 |
AUC
CUS0.769
CEUS0.848
CUS + CEUS0.934
- CEUS vs CUS: P > 0.05 — no significant difference
- CUS + CEUS vs CEUS: P < 0.05 — higher with CUS + CEUS
- CUS + CEUS vs CUS: P < 0.05 — higher with CUS + CEUS
Further findings
Final diagnosis of nodules
- Benign
- 40 (34.5%)
- Malignant
- 76 (65.5%)
Independent risk factors for malignancy (multivariate logistic regression)
- Taller-than-wide, irregular margin, microcalcification, hypo-enhancement, heterogeneous enhancement, synchronous/slower wash in and synchronous/slower wash out were independent risk factors (all p < 0.05)
Original publication
Contrast‐Enhanced Ultrasound for Diagnosing Thyroid Nodules With Indeterminate Cytology: A Retrospective Study. Clin Endocrinol (Oxf). Published 6 November 2024. doi:10.
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