Significance of FDG–PET standardized uptake values in predicting thyroid disease
Main finding · Abnormal thyroid function by mean SUVResult — go to the resultRelative risk 4.6Authors' conclusion
Mean SUV ≥ 2 was strongly associated with abnormal thyroid function in this large cohort, indicating that mean SUV with FDG-PET/CT can be used as a criterion for thyroid evaluation. Preliminarily, this study shows the potential utility of detecting thyroid dysfunction based on imaging findings.
Study context
- Population
- FDG-PET/CT scans; thyroid function categorized into three groups by serum TSH
- Participants
- 7,013 FDG-PET/CT scans
- Exposure
- Mean thyroid FDG standardized uptake value (SUV) ≥2 vs <2
- Outcome
- Standardized cut-off value for abnormal FDG accumulation in the thyroid gland; risk for thyroid dysfunction by mean SUV
Methodological detailsautomatic thyroid segmentation (2D- and 3D-U-net), machine learning (LightGBM)
- Automatic thyroid segmentation (2D- and 3D-U-net)
- Machine learning (LightGBM)
Main finding
Abnormal thyroid function by mean SUV
Relative risk
4.6
As reported in the abstract
- Normal group with mean SUV < 2
- 98.9%
- Participants with mean SUV < 2 who had normal thyroid function
- 93.8%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Detection of thyroid dysfunction with LightGBM | LightGBM sensitivity 14.5 · specificity 99% |
- Detection of thyroid dysfunction with LightGBM: explanatory variables: age, sex, height, weight, CT value, volume, mean SUV
Original publication
Significance of FDG–PET standardized uptake values in predicting thyroid disease. Eur Thyroid J. Published 25 January 2023. doi:10.
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