Association of Thyroid-Stimulating Hormone With All-Cause Mortality: A 2-Sample Mendelian Randomization Study
Authors' conclusion
Higher TSH levels were causally associated with lower risk of all-cause mortality, which may be largely attributed to respiratory disease mortality.
Study context
- Population
- UK Biobank participants recruited from 22 assessment centers across the UK, 2006–2010; 70 thyroid-stimulating hormone (TSH)-associated single-nucleotide polymorphisms (SNPs) (P < 5 × 10–8) as instrumentsUK Biobank
- Participants
- 384,344 participants
- Comparison
- Genetically predicted TSH levels
- Outcome
- All-cause mortality
- Follow-up
- Median 9.00 years
Methodological detailsgenetic risk score, Cox proportional hazards regression, UK Biobank
- Genetic risk score
- Cox proportional hazards regression
- UK Biobank
Performance
As reported in the abstract
Estimate (95% CI)P value
1 SD increase in TSHmain MR analysis
OR 0.972(0.948–0.996)
Middle TSH GRSvs Lowest TSH GRS
multivariable HR 0.976(0.940–1.014)
Highest TSH GRSvs Lowest TSH GRS
multivariable HR 0.947(0.911–0.985)
P < 0.01for trendFurther findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Respiratory disease mortality | 0.881 (0.805–0.963) | |
| 0.512Odds ratio (log scale) |
Mortality from CVD, cancer, noncancer diseases and dementia; digestive diseases
- Genetically predicted TSH negatively associated with mortality from CVD, cancer, noncancer diseases and dementia, not statistically significant; except digestive diseases mortality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of Thyroid-Stimulating Hormone With All-Cause Mortality: A 2-Sample Mendelian Randomization Study. J Clin Endocrinol Metab. Published 20 January 2023. doi:10.
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