Thyroid function in infants born to women with hypothyroidism: An observational study at an Australian tertiary perinatal centre
Authors' conclusion
Infants born to women with hypothyroidism (including autoimmune hypothyroidism) had normal thyroid function in the early neonatal period. A small proportion of infants may develop TSH levels > 10 mU/L that normalizes by 4 weeks of age. The practice of routine thyroid function testing for this cohort in addition to newborn screening test offers no additional benefit.
Study context
- Population
- Healthy full-term infants (≥37 weeks gestation) born to women with hypothyroidism, including non-Graves' autoimmune hypothyroidism, over a 3-year period; preterm infants and those born to women with GD or thyroidectomy excluded
- Participants
- 790 mother-infant dyads
- Outcome
- Thyroid dysfunction on routine thyroid function test
- Follow-up
- Around 2 weeks of age
Methodological detailssingle centre
- Single centre
Main finding
As reported in the abstract
Normal thyroid function
780 infants
99%
Thyroid stimulating hormone (TSH) > 10mIU/L
10 infants (1%); range 10.25-106.37 mU/L
Observational data: associations, not effects.
Further findings
Follow-up of infants with TSH >10 mIU/L at 2 weeks
- Follow-up thyroid function normalized
- 9 infants
- Congenital hypothyroidism identified by routine newborn screening test
- 1 infant
TSH >10 mIU/L in infants of women with known anti-thyroid antibodies · 2 weeks of age
- No infant born to women with known anti-thyroid antibodies had TSH >10 mIU/L
Normal thyroid function where maternal anti-thyroid antibodies not known
- Normal thyroid function
- 125/133, 94%
Original publication
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