Thyroid Dysfunction Risk After Iodinated Contrast Media Administration: A Prospective Longitudinal Cohort Analysis
Authors' conclusion
There is a rare long-term risk of an excess iodine load on thyroid dysfunction even among individuals from an overall iodine-sufficient region, supporting the need for targeted monitoring following iodinated contrast administration.
Study context
- Population
- Patients in the US Veterans Affairs medical system who received iodinated contrast media; median age 70.0 years (IQR 62.2–74.0), 98.4% male
- Participants
- 122 patients
- Outcome
- Long-term risk of thyroid dysfunction following iodinated contrast administration
- Follow-up
- Up to 36 months
Main finding
As reported in the abstract
Iodine-induced thyroid dysfunction · median follow-up 18 months
Iodine-induced thyroid dysfunction
11.5%
14/122
Hyperthyroidism (including 1 overt)
6
4.9%
Subclinical hypothyroidism
8
6.6%
Observational data: associations, not effects.
Further findings
Persistent subclinical hyperthyroidism or hypothyroidism at last follow-up
- Persistent dysfunction among subjects with thyroid dysfunction (14 new-onset, 6 preexisting)
- 10 of 20
Baseline subclinical thyroid dysfunction
- Subclinical thyroid dysfunction before iodinated contrast media (ICM)
- 6
Longitudinal thyroid hormone changes
- Subtle changes in thyroid hormones within reference ranges in overall cohort
Original publication
Thyroid Dysfunction Risk After Iodinated Contrast Media Administration: A Prospective Longitudinal Cohort Analysis. J Clin Endocrinol Metab. Published 3 May 2024. doi:10.
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