Lipids & metabolic liver disease
Investigating multimorbidity trajectories in people living with MASLD diagnosis: A trajectory analysis using the UK Biobank
Authors' conclusion
People living with MASLD demonstrated multimorbidity trajectories involving co-occurrence of metabolic diseases, chronic inflammation, and cardiovascular diseases. If replicated, these pathways may serve as promising targets to improve late-life health in individuals with MASLD.
Study context
- Population
- People with MASLD in UK Biobank; median age 59 (52–64) years, 65.6% malematched cohort
- Exposure
- MASLD vs propensity-matched non-MASLD controls
- MASLDn = 137,859
- Outcome
- Multimorbidity trajectories of chronic diseases post-MASLD diagnosis
- Follow-up
- 13 years
Methodological detailspropensity score matching, UK Biobank, phenome-wide association analysis
- Propensity score matching
- UK Biobank
- Phenome-wide association analysis
Main finding
As reported in the abstract
Multimorbidity trajectories post-MASLD diagnosis · Over 13 years of follow-up
Diseases with elevated risks post-MASLD diagnosis (PheWAS)
128
Common trajectories
6637
Diseases involved in common trajectories
69
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Obesity | 8.77 (8.37–9.18) | |
| Diabetes | 4.34 (4.15–4.53) | |
| Sleep disorders | 3.21 (3.01–3.42) | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Investigating multimorbidity trajectories in people living with MASLD diagnosis: A trajectory analysis using the UK Biobank. Diabetes Obes Metab. Published 8 September 2025. doi:10.
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