Interaction between plasma phospholipid odd-chain fatty acids and GAD65 autoantibodies on the incidence of adult-onset diabetes: the EPIC-InterAct case–cohort study
Authors' conclusion
Low plasma phospholipid 17:0 concentrations may promote the progression from GAD65Ab positivity to adult-onset diabetes.
Study context
- Population
- EPIC-InterAct: incident adult-onset diabetes cases and a randomly selected subcohort11,124 cases
- Exposure
- 1 SD lower plasma phospholipid odd-chain fatty acids (OCFA) by GAD65Ab status
- Outcome
- Incidence of adult-onset diabetes
Methodological detailsEuropean, Prentice-weighted Cox regression, adjusted
- European
- Prentice-weighted Cox regression
- Adjusted
Main finding
As reported in the abstract
Adult-onset diabetes per 1 SD lower OCFA, particularly 17:0
Hazard ratio (95% CI)
GAD65Ab-negative
1.55(1.48–1.64)
GAD65Ab-positive
1.69(1.34–2.13)
Per 1 SD lower OCFA, as printed
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Joint exposure: low 17:0 and high GAD65Ab positivityvs high 17:0 and GAD65Ab negativity; diabetes incidence | 7.51 (4.83–11.69) | |
| 0.050.21520Hazard ratio (log scale) |
- Joint exposure: low 17:0 and high GAD65Ab positivity vs high 17:0 and GAD65Ab negativity; diabetes incidence — Evidence of additive interaction: proportion attributable to interaction (AP), 95% CI 0.05, 0.45
- 0.25
Low dairy intake and diabetes incidence, GAD65Ab-negative
- HR (95% CI 0.94, 1.02); not associated
- 0.98
Low dairy intake and diabetes incidence, GAD65Ab-positive
- HR (95% CI 0.79, 1.18); not associated
- 0.97
Original publication
Interaction between plasma phospholipid odd-chain fatty acids and GAD65 autoantibodies on the incidence of adult-onset diabetes: the EPIC-InterAct case–cohort study. Diabetologia. Published 10 June 2023. doi:10.
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