Patients with prediabetes are at greater risk of developing diabetes 5 months postacute SARS-CoV-2 infection: a retrospective cohort study
Authors' conclusion
SARS-CoV-2 infection confers a higher risk for developing persistent diabetes 5 months post-COVID-19 in patients with prediabetes who were hospitalized for COVID-19 compared with COVID-19-negative counterparts with prediabetes. In-hospital diabetes, critical illness, and elevated HbA1c are risk factors for developing persistent diabetes. Patients with prediabetes with severe COVID-19 disease may need more diligent monitoring for developing P-DM postacute SARS-CoV-2 infection.
Study context
- Population
- Patients with history of prediabetes, Montefiore Health System, Bronx, New York, March 11, 2020 to August 17, 2022propensity matched
- Participants
- 3,102 vs 9,306
- Exposure
- COVID-19 vs no COVID-19 in patients with prediabetes
- COVID-19n = 3,102
- Controlsn = 9,306reference
- Outcome
- New-onset in-hospital DM (I-DM) and new-onset persistent DM (P-DM)
- Follow-up
- 5 months after SARS-CoV-2 infection
Methodological detailspropensity-matched controls, electronic medical record data
- Propensity-matched controls
- Electronic medical record data
Main finding
As reported in the abstract
I-DM and P-DM, hospitalized patients · 5 months postinfection (P-DM)
- COVID-19 vs Without COVID-19: P < 0.001
- COVID-19 vs Without COVID-19: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| P-DM, non-hospitalized · 5 monthsCOVID-19 vs Without COVID-19 · similar incidence: 4.15% and 4.1% | P > 0.05 |
Predictors of I-DM
- Critical illness, HR
- 4.6 (3.5 to 6.1), p<0.005 (95% CI)
- In-hospital steroid treatment, HR
- 2.88 (2.2 to 3.8), p<0.005 (95% CI)
- SARS-CoV-2 infection status, HR
- 1.8 (1.4 to 2.3), p<0.005 (95% CI)
- Hemoglobin A1c (HbA1c), HR
- 1.7 (1.6 to 1.8), p<0.005 (95% CI)
Predictors of persistent diabetes mellitus (P-DM) at follow-up
- I-DM, HR
- 23.2 (16.1 to 33.4), p<0.005 (95% CI)
- Critical illness, HR
- 2.4 (1.6 to 3.8), p<0.005 (95% CI)
- HbA1c, HR
- 1.3 (1.1 to 1.4), p<0.005 (95% CI)
Original publication
Patients with prediabetes are at greater risk of developing diabetes 5 months postacute SARS-CoV-2 infection: a retrospective cohort study. BMJ Open Diabetes Res Care. Published 9 June 2023. doi:10.
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