Risk phenotypes of diabetes and association with COVID-19 severity and death: an update of a living systematic review and meta-analysis
Authors' conclusion
Individuals with a more severe course of diabetes and pre-existing comorbidities had a poorer prognosis of COVID-19 than individuals with a milder course of the disease.
Study context
- Population
- Individuals with diabetes and confirmed SARS-CoV-2 infection; searches to 14 February 2022, PubMed alert to 1 December 2022169 articles
- Participants
- ≈900,000 individuals
- Comparison
- High-risk phenotypes of diabetes vs other phenotypes
- Outcome
- COVID-19-related death and severity
Methodological detailsfirst update, random-effects meta-analysis, Quality in Prognosis Studies (QUIPS) risk of bias, GRADE certainty of evidence, Observational studies; residual or unmeasured confounding cannot be ruled out
- First update
- Random-effects meta-analysis
- QUIPS risk of bias
- GRADE certainty of evidence
- Observational studies; residual or unmeasured confounding cannot be ruled out
Pooled result
As reported in the abstract
COVID-19-related death: new evidence (moderate to high certainty)
- Obesity, SRR (95% CI), n=21 studies
- 1.18 [1.04, 1.34]
- HbA1c 53-75 mmol/mol [7-9%], n=8
- 1.18 [1.06, 1.32]
- Chronic GLP-1 RA use, n=9
- 0.83 [0.71, 0.97]
- Pre-existing HF, n=14
- 1.33 [1.21, 1.47]
- Pre-existing liver disease, n=6
- 1.40 [1.17, 1.67]
- Charlson index per 1 unit increase, n=2
- 1.33 [1.13, 1.57]
- C-reactive protein per 5 mg/l increase, n=10
- 1.07 [1.02, 1.12]
- Aspartate aminotransferase per 5 U/l increase, n=5
- 1.28 [1.06, 1.54]
- eGFR per 10 ml/min per 1.73 m² increase, n=6
- 0.80 [0.71, 0.90]
- Lactate dehydrogenase per 10 U/l increase, n=7
- 1.03 [1.01, 1.04]
- Lymphocyte count per 1×109/l increase, n=6
- 0.59 [0.40, 0.86]
Further pooled results
COVID-19 severity
- Existing COVID-19 vaccination, SRR (95% CI), n=3
- 0.32 [0.26, 0.38]
- Pre-existing hypertension, n=49
- 1.23 [1.14, 1.33]
- Similar associations as for death; new evidence on neuropathy, cancer and high IL-6 levels
Original publication
Risk phenotypes of diabetes and association with COVID-19 severity and death: an update of a living systematic review and meta-analysis. Diabetologia. Published 19 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →