Associations of genetic markers of diabetes mellitus with carotid atherosclerosis: a community-based case–control study
Authors' conclusion
We identified 9 DM SNPs showing promising associations with CP. The multi-locus GRSs may be used as biomarkers for the identification and prediction of high-risks subjects for atherosclerosis and atherosclerotic diseases. Future studies on these specific SNPs and their associated genes may provide valuable information for the preventions of DM and atherosclerosis.
Study context
- Population
- Subjects randomly selected from a community-based cohort
- Participants
- 309 vs 439
- Comparison
- Top significant diabetes mellitus (DM) single nucleotide polymorphism (SNPs) in subjects with vs without carotid plaque
- Carotid plaque (CP)-positiven = 309
- CP-negativen = 439reference
- Outcome
- Association of top significant DM SNPs with carotid atherosclerosis (presence of CP)
Methodological detailscommunity-based, multivariable logistic regression
- Community-based
- Multivariable logistic regression
Main finding
As reported in the abstract
CP-positive
9.19
mean · SD 1.53
CP-negative
8.62
mean · SD 1.63
P < 0.001
- SNPs with promising associations with CP (rs4712524, rs1150777, rs10842993, rs2858980, rs9583907, rs1077476, rs7180016, rs4383154, rs9937354)
- 9
- SNPs with significantly independent effects (rs9937354, rs10842993, rs7180016, rs4383154)
- 4
- Multivariable-adjusted OR of CP per 1.0 increase in 9-GRS
- 1.30 (95% CI 1.18-1.44; p = 4.7 × 10-7)
Further findings
| Outcome | CP-positive | Multivariable-adjusted OR (95% CI) | P value |
|---|---|---|---|
| 4-locus GRS (4-GRS) | mean 4.02 (SD 0.81) | P < 0.001 | |
| Odds of CP per 1.0 increase in 4-GRSEstimate outside its printed CI | 1.47 (1.74–9.40) | P = 6.1 × 10-5 |
Multi-locus GRSs in DM patients
- Mean multi-locus GRSs of DM patients similar to CP-positive subjects and higher than CP-negative or DM-negative subjects
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Associations of genetic markers of diabetes mellitus with carotid atherosclerosis: a community-based case–control study. Cardiovasc Diabetol. Published 9 March 2023. doi:10.
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