Causal Associations Between Age at Diagnosis of Diabetes and Cardiovascular Outcomes: A Mendelian Randomization Study
Authors' conclusion
Our findings provide novel evidence that genetically determined diabetes subgroups by age at diagnosis have similar causal effects on CVD and cardiometabolic risks.
Study context
- Population
- UK Biobank diabetes GWAS (24,986 cases/187,130 controls); outcomes from European-descent genome-wide association study (GWASs)24,986 cases/187,130 controls
- Comparison
- Genetically determined diabetes by age at diagnosis
- Outcome
- 5 type-specific cardiovascular diseases (CVDs) (stroke, MI, HF, AF, CVD mortality) and 11 cardiometabolic traits
Methodological details2-sample Mendelian randomization, inverse variance-weighted main analysis, several sensitivity analyses
- 2-sample Mendelian randomization
- Inverse variance-weighted main analysis
- Several sensitivity analyses
Main finding
As reported in the abstract
- Increased risk of stroke
- 5-8%
- Increased risk of MI
- 8-10%
- Higher systolic blood pressure
- 0.56-0.94 mmHg
- Higher WHR
- 0.003-0.004
- Lower BMI
- 0.31-0.42 kg/m²
- Lower waist circumference
- 0.68-0.99 cm
- Lower hip circumference
- 0.57-0.80 cm
Further findings
Outcomes associated in specific age groups
- Increased risk of HF
- 4%
- Increased CVD mortality
- 8%
- Higher diastolic blood pressure
- 0.20 mmHg
- Higher TG
- 0.06 SD
- Lower HDL-C
- 0.02 mmol/L
Original publication
Causal Associations Between Age at Diagnosis of Diabetes and Cardiovascular Outcomes: A Mendelian Randomization Study. J Clin Endocrinol Metab. Published 14 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →