Causal association of modifiable factors with cardiometabolic multimorbidity: an exposome-wide Mendelian randomization investigation
Authors' conclusion
Promoting educational attainment, maintaining favorable serum urate, and controlling obesity are specifically prioritized for CMM prevention. Furthermore, avoiding smoking and sedentary behavior, and strengthening physical activity held prominent protective impacts on CMDs. Additionally, improving dyslipidemia and dysglycemia, maintaining favorable blood pressure, and enhancing lung function, would contribute to the co-management of CMDs and preventing the long-term CMM condition. Our investigation provided causality-oriented evidence to establish the risk profile of CMM.
Study context
- Population
- Large-scale genome-wide association study (GWAS) data from GWAS Catalog; Cardiometabolic multimorbidity (CMM) = co-existence of ≥2 cardiometabolic diseases (CMDs) (T2D, coronary artery disease (CAD), stroke)23 modifiable factors
- Comparison
- Genetically predicted modifiable factors and CMM and CMDs
- Outcome
- CMM
Methodological detailsthree-stage design, two-sample Mendelian randomization (MR) with sample overlap correction and multiple testing, multivariable MR, multi-response MR, exposome-wide
- Three-stage design
- Two-sample MR with sample overlap correction and multiple testing
- Multivariable MR
- Multi-response MR
- Exposome-wide
Main finding
As reported in the abstract
- Educational attainment, OR
- 0.858 (0.834-0.883) (95% CI)
- Household income, OR
- 0.794 (0.720-0.875) (95% CI)
- Lifetime smoking behavior, OR
- 1.201 (1.145-1.260) (95% CI)
- Leisure screen time, OR
- 1.255 (1.186-1.327) (95% CI)
- LDL-C, OR
- 1.062 (1.046-1.079) (95% CI)
- Total cholesterol, OR
- 1.045 (1.029-1.062) (95% CI)
- Apolipoprotein B, OR
- 1.035 (1.019-1.051) (95% CI)
- Fasting glucose, OR
- 1.096 (1.038-1.157) (95% CI)
- HbA1c, OR
- 1.062 (1.037-1.089) (95% CI)
- Systolic blood pressure, OR
- 1.125 (1.104-1.146) (95% CI)
- Diastolic blood pressure, OR
- 1.104 (1.083-1.126) (95% CI)
- FEV1, OR
- 0.953 (0.931-0.975) (95% CI)
- Body mass index (BMI), OR
- 1.243 (1.210-1.277) (95% CI)
Further findings
Multivariable MR: independent associations with CMM within a single domain
- Household income, lifetime smoking, HbA1c, systolic blood pressure and FEV1 independently associated with CMM
Each CMD
- Similar results observed in each CMD
Multi-response MR
- Reinforcing evidence for educational attainment, serum urate and BMI with CMM, and lifetime smoking, moderate to vigorous physical activity and leisure screen time with diverse CMDs
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →