ApoC-III and ectopic fat accumulation in individuals with type 2 diabetes: an exploratory analysis from the MEDEA randomised controlled study
Authors' conclusion
A multifactorial diet significantly reduced plasma ApoC-III levels in individuals with type 2 diabetes. Independent of dietary intervention, lower ApoC-III levels were associated with reduced liver and pancreatic fat accumulation and improved beta cell function.
Study context
- Population
- Individuals with T2D (20 men, 16 women), aged 35–75 years
- Participants
- 36 individuals
- Comparison
- Multifactorial diet vs monounsaturated fatty acid (MUFA)-rich diet
- Multifactorial dietn = 20
- MUFA dietn = 16reference
- Primary endpoint
- Plasma ApoC-III levels (fasting and postprandial) and their relationship with ectopic fat and beta cell function
- Follow-up
- 8 weeks
Methodological detailsparallel group, isoenergetic diets
- Parallel group
- Isoenergetic diets
Primary result
As reported in the abstract
Change (8 week minus baseline) in ApoC-III
| Group | Value | Postprandial ApoC-III AUC change |
|---|---|---|
| Multifactorial diet | −0.006 ± 0.040 g/l | −1.34 ± 6.01 g/l × 180 min |
| MUFA diet | +0.007 ± 0.048 g/l | +1.60 ± 5.56 g/l × 180 min |
Value
Multifactorial diet−0.006 ± 0.040 g/l
MUFA diet+0.007 ± 0.048 g/l
Postprandial ApoC-III AUC change
Multifactorial diet−1.34 ± 6.01 g/l × 180 min
MUFA diet+1.60 ± 5.56 g/l × 180 min
- Multifactorial diet vs MUFA diet: P = 0.070
- Multifactorial diet vs MUFA diet: P = 0.043
Further findings
Correlations of ApoC-III changes with ectopic fat and beta cell function, regardless of diet
- Fasting ApoC-III change vs liver fat change
- r=0.357, p=0.032
- Fasting ApoC-III change vs pancreatic fat change
- r=0.385, p=0.020
- Fasting ApoC-III change vs beta cell function
- r=−0.384, p=0.026
- Postprandial ApoC-III change vs beta cell function
- r=−0.402, p=0.018
Original publication
ApoC-III and ectopic fat accumulation in individuals with type 2 diabetes: an exploratory analysis from the MEDEA randomised controlled study. Diabetologia. Published 5 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →