A multicomponent health care intervention is associated with improved glycaemic control in subjects with poorly controlled type 2 diabetes compared with routine care: The INTEGRA study
Main finding · Change in HbA1cResult — go to the resultMean difference −0.66 % (−7 mmol/mol) 95% CI −0.4 to −1.0Authors' conclusion
A multifaceted intervention oriented at reducing therapeutic inertia by primary care physicians was associated with greater improvement in glycaemic control compared with patients treated as per usual care.
Study context
- Population
- Primary care patients with T2D and HbA1c >9% (75 mmol/mol)matched controls
- Participants
- 225 vs 675
- Exposure
- Multicomponent health care intervention vs usual care
- Interventionn = 225
- Usual caren = 675reference
- Outcome
- Change in HbA1c between groups
- Follow-up
- 12 months
Methodological detailsmatched controls from electronic medical records, primary care
- Matched controls from electronic medical records
- Primary care
Main finding
Change in HbA1c
Mean difference
−0.66 % (−7 mmol/mol)
95% CI −0.4 to −1.0
P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
HbA1c <7% achieved
P < 0.001
HbA1c <8% achieved
P < 0.001
- Glucose-lowering therapy intensification · 0-3 and 6-12 months — Significant increase in patients prescribed ≥2 antidiabetic therapies with Intervention · more frequent intensification with Intervention
- P < 0.001 · P < 0.001
Durability of HbA1c improvement
- HbA1c fell substantially in both groups after 3 months; improvement sustained throughout only with Intervention
Original publication
A multicomponent health care intervention is associated with improved glycaemic control in subjects with poorly controlled type 2 diabetes compared with routine care: The INTEGRA study. Diabetes Obes Metab. Published 22 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →