Insulin resistance and abdominal adiposity discriminate early vascular aging (higher vascular risk) in adults with type 1 diabetes without cardiovascular events
Authors' conclusion
In adults with T1D without cardiovascular events, higher IR is associated with vascular aging driven by abdominal adiposity. Simple measures of abdominal adiposity (WHtR, WC) effectively discriminate those adults with EVA.
Study context
- Population
- Adults with T1D without cardiovascular events; 48.6 % female, aged 41.2[13.1] years, disease duration 16[12–23] years18 with early vascular aging (EVA)
- Participants
- 179 adults
- Exposure
- Discrimination of EVA by eIS vs measures of abdominal adiposity
- Outcome
- Association between insulin resistance (IR) (eIS) and arterial stiffness (aPWV), and discrimination of EVA (aPWV > 10 m/s)
Main finding
As reported in the abstract
| Group | Cutoff | C-statistic |
|---|---|---|
| eIS | <7.10 mg/kg/min | 0.77[0.66-0.88] |
| WHR | >0.93 | 0.77[0.66-0.88] |
| WC | >90.8 cm | 0.87[0.81-0.93] |
| WHtR | >0.56 | 0.91[0.85-0.96] |
Cutoff
eIS<7.10 mg/kg/min
WHR>0.93
WC>90.8 cm
WHtR>0.56
C-statistic
eIS0.77[0.66-0.88]
WHR0.77[0.66-0.88]
WC0.87[0.81-0.93]
WHtR0.91[0.85-0.96]
- Between WHR and eIS: P = 1.000 — performed similarly
- WC vs eIS: P = 0.025 — eIS outperformed by WC
- WHtR vs eIS: P = 0.011 — eIS outperformed by WHtR
- Independent association between eIS and aPWV (ß)
- −0.218, P < 0.001
- Association mainly driven by WHR
- P < 0.001
Observational data: associations, not effects.
Further findings
Baseline aPWV and eIS
- aPWV
- 7.1[6.1-8.4] m/s
- eIS
- 8.59[6.12-10.00] mg/kg/min
Original publication
Insulin resistance and abdominal adiposity discriminate early vascular aging (higher vascular risk) in adults with type 1 diabetes without cardiovascular events. Diabetes Res Clin Pract. Published 19 November 2025. doi:10.
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