Type 1 diabetes

Listening to Hypoglycemia: Voice as a Biomarker for Detection of a Medical Emergency Using Machine Learning

Diabetes CarePublished Diagnostic accuracy study

Authors' conclusion

An ML approach exclusively based on voice data allows for noninvasive hypoglycemia detection, corroborating the potential of ML-based approaches to infer acute health states through voice.

Study context

Population
People with T1D; 11 female, age 37.3 ± 12.4 years, HbA1c 7.1 ± 0.5%; 540 smartphone voice recordings
Participants
22 people540 recordings
Comparison
Machine learning (ML) voice-based detection of hypoglycemia by speech task
Outcome
Noninvasive detection of hypoglycemia from voice features (AUC)
Methodological detailsmachine learning, two sequential clinical studies, standardized euglycemia and hypoglycemia
  • Machine learning
  • Two sequential clinical studies
  • Standardized euglycemia and hypoglycemia

Performance

As reported in the abstract

Hypoglycemia detection, AUC
Test or modelValueAUC
Reading text aloud0.90 ± 0.120.90 ± 0.12
Diadochokinetic task0.87 ± 0.150.87 ± 0.15

Value

Reading text aloud0.90 ± 0.12
Diadochokinetic task0.87 ± 0.15

AUC

Reading text aloud0.90 ± 0.12
Diadochokinetic task0.87 ± 0.15

Original publication

Listening to Hypoglycemia: Voice as a Biomarker for Detection of a Medical Emergency Using Machine Learning. Diabetes Care. Published 18 November 2025. doi:10.2337/dc25-1680

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