Insulin Receptor Family Autoantibodies in Patients with Type B Insulin Resistance
Authors' conclusion
This study validates an InsR-aAb assay in the largest TBIR cohort to date and identifies a novel association between IRRR-aAb and bicarbonate excretion. While InsR-aAb were detected in other IR disorders, pathogenic effects were specific to TBIR.
Study context
- Population
- Patients with Type B insulin resistance (TBIR) and non-autoimmune insulin resistance (IR)
- Exposure
- TBIR vs non-autoimmune IR
- Outcome
- Diagnostic performance of InsR-aAb immune-luminometric assay for distinguishing TBIR from non-autoimmune IR
Methodological detailsdiagnostic accuracy (ROC analysis)
- Diagnostic accuracy (ROC analysis)
Main finding
As reported in the abstract
InsR-aAb assay: optimal cutoff for TBIR vs non-autoimmune IR
AUC
0.96
Sensitivity
91.3%
Specificity
93.9%
Observational data: associations, not effects.
Further findings
Autoantibody titers vs biomarkers in TBIR
- Higher InsR-aAb titers associated with increased HbA1c, glucose, insulin and lower IGF-1z
- all P < .0001
- Higher insulin receptor-related receptor (IRRR)-aAb titers associated with lower CO2
- P = 0.04
Autoantibody titers vs biomarkers in non-autoimmune IR
- IGF-1z increased with mild IR
- P = 0.005
- IGF-1z decreased with severe IR
- P = 0.01
- Autoantibody titers not associated with glycemia biomarkers
Original publication
Insulin Receptor Family Autoantibodies in Patients with Type B Insulin Resistance. J Clin Endocrinol Metab. Published 12 January 2026. doi:10.
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