The impact of family history of type 2 diabetes on clinical heterogeneity in idiopathic type 1 diabetes
Authors' conclusion
Family history of T2D may be implicated in the heterogeneity of idiopathic T1D patients.
Study context
- Population
- Patients with idiopathic T1D (clinically diagnosed T1D, after excluding autoimmune T1D by islet autoantibody testing and monogenic diabetes by a gene panel)
- Participants
- 335 patients
- Exposure
- T2D family history vs no T2D family history
- Outcome
- Clinical phenotype by T2D family history
Methodological detailssubgroup analysis by HLA genotype, multivariable analysis
- Subgroup analysis by HLA genotype
- Multivariable analysis
Main finding
As reported in the abstract
- Idiopathic T1D with a T2D family history
- 18.2%
- T2D family history: older age of onset, higher BMI at diagnosis, lower insulin dosage, higher fasting and 2-hour postprandial C-peptide (better beta-cell function)
- all P < 0.05
Observational data: associations, not effects.
Further findings
Subgroups by HLA susceptible genotypes
- Impact of T2D family history consistently observed regardless of HLA susceptible genotypes
Risk of beta-cell function failure (multivariable)
- T2D family history negatively correlated with risk of beta-cell function failure
- P < 0.05
Original publication
The impact of family history of type 2 diabetes on clinical heterogeneity in idiopathic type 1 diabetes. Diabetes Obes Metab. Published 2 November 2022. doi:10.
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