The independent association of myocardial extracellular volume and myocardial blood flow with cardiac diastolic function in patients with type 2 diabetes: a prospective cross-sectional cohort study
Authors' conclusion
In patients with type 2 diabetes, imaging biomarkers of microvascular dysfunction and diffuse fibrosis impacts diastolic dysfunction independently of each other. Microvascular dysfunction primarily affects early left ventricular relaxation. Diffuse fibrosis primarily affects diastasis.
Study context
- Population
- Patients with T2D and controls; Myocardial blood flow (MBF) at rest and adenosine-stress, MPR and ECV by cardiovascular magnetic resonance (CMR)
- Participants
- 205 vs 25
- Exposure
- T2D vs Controls
- T2Dn = 205
- Controlsn = 25reference
- Outcome
- Independent associations of ECV, stress MBF and MPR with diastolic parameters (multivariable, adjusted incl. each other)
Methodological detailsprospective
- Prospective
Main finding
As reported in the abstract
- 10% ECV increase: Early peak filling rate (ePFR)/EDV β, rest
- - 4.0%
- 10% ECV increase: ePFR/EDV β, stress
- - 7.9%
- 10% ECV increase: LAmax/BSA β, rest
- 4.8%
- 10% ECV increase: LAmax/BSA β, stress
- 5.8%
- 10% ECV increase: circumferential peak diastolic strain rate (PDSR) β
- - 4.1%
- 10% ECV increase: radial PDSR β
- 0.07%/sec
- 10% stress MBF increase: lateral e' β
- 1.4%
- 10% stress MBF increase: average E/e' β
- - 1.4%
- 10% MPR increase: lateral e' β
- 2.7%
- 10% MPR increase: average E/e' β
- - 2.8%
Observational data: associations, not effects.
Original publication
The independent association of myocardial extracellular volume and myocardial blood flow with cardiac diastolic function in patients with type 2 diabetes: a prospective cross-sectional cohort study. Cardiovasc Diabetol. Published 31 March 2023. doi:10.
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