Cardiac magnetic resonance quantified epicardial fat volume is associated with complex coronary artery disease among diabetics
Authors' conclusion
Increased epicardial adipose tissue was a significant independent predictor of severe and complex CAD, representing a possible risk marker and potential therapeutic target, particularly among diabetics.
Study context
- Population
- Patients with CAD on coronary angiography who underwent cardiac magnetic resonance (CMR)
- Participants
- 111 patients
- Exposure
- Diabetic vs non-diabetic patients; CMR-quantified EFV and PFV vs CAD complexity (syntax score)
- Diabeticn = 64
- Outcome
- Correlation of CMR-quantified EFV and PFV with CAD complexity (syntax score)
Main finding
As reported in the abstract
EFV ≥ 119.55 ml predicted high syntax score (SS): AUC
0.84
95% CI 0.76–0.91
EFV ≥ 119.55 ml for high SS: sensitivity
77%
EFV ≥ 119.55 ml for high SS: specificity
82.5%
Observational data: associations, not effects.
Further findings
Diabetic vs non-diabetic: SS and EFV/PFV
- Diabetics had significantly higher SS and larger absolute and indexed EFV and PFV than non-diabetics
EFV cutoffs for high SS in diabetics and non-diabetics
- Different EFV cutoffs significantly predicted high SS in both subgroups with reasonable sensitivity and specificity
Original publication
Cardiac magnetic resonance quantified epicardial fat volume is associated with complex coronary artery disease among diabetics. Cardiovasc Diabetol. Published 7 February 2025. doi:10.
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