A sex-disaggregated analysis of the prognostic value of lean type 2 diabetes mellitus in the adult population with acute myocardial infarction
Authors' conclusion
The lean T2DM phenotype was present in one-quarter of the AMI cohort with T2DM. The lean T2DM phenotype was an independent predictor of long-term mortality following AMI, although this association was stronger in males than in females.
Study context
- Population
- Adults with acute MI
- Participants
- 9,545 adults
- Exposure
- Lean T2D vs other T2D/body phenotypes
- Lean T2DMn = 1,324
- Outcome
- Long-term all-cause mortality
- Follow-up
- Mean 3.4 ± 2.4 years
Methodological detailssex-stratified analysis, Cox regression adjusted for age, ethnicity, previous acute myocardial infarction (AMI), AMI type, CKD, ACE inhibitor/ARB, beta-blockers, smoking
- Sex-stratified analysis
- Cox regression adjusted for age, ethnicity, previous AMI, AMI type, CKD, ACE inhibitor/ARB, beta-blockers, smoking
Main finding
As reported in the abstract
Lean T2DM
32.6%
- Lean T2DM independent predictor of mortality, aHR (95% CI 1.040-1.319, p = 0.009), adjusted
- 1.171
- Males, aHR
- 1.201 (95% CI 1.037-1.391, p = 0.015)
- Females, aHR
- 1.066 (95% CI 0.869-1.308, p = 0.538)
- Highest rate in lean T2DM, p < 0.001
- 32.6%
Observational data: associations, not effects.
Further findings
Phenotype distribution
| Outcome | Lean T2DM | Non-lean T2DM | Lean non-T2DM | Non-lean non-T2DM |
|---|---|---|---|---|
| Heart failure | 23.3% | — not stated in the abstract | — not stated in the abstract | — not stated in the abstract |
| Cardiogenic shock | 9.1% | — not stated in the abstract | — not stated in the abstract | — not stated in the abstract |
— not stated in the abstract
- Phenotype distribution — Non-lean share within T2DM
- 74.5%
- Heart failure — Highest rate in lean T2DM, p < 0.001
- 23.3%
- Cardiogenic shock — Highest rate in lean T2DM, p = 0.036
- 9.1%
Phenotype distribution
- Lean T2DM tended to be female and older
Original publication
A sex-disaggregated analysis of the prognostic value of lean type 2 diabetes mellitus in the adult population with acute myocardial infarction. Cardiovasc Diabetol. Published 7 February 2025. doi:10.
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