The prognostic impact of insulin resistance surrogates in patients with acute myocardial infarction with and without type 2 diabetes
Authors' conclusion
TyG index was an independent risk factor for in-hospital death in patients with STEMI or NSTEMI. TyG index, TyG-BMI and METS-IR were not independent risk factors for MACCE at 12 month follow-up. TyG index and METS-IR have low predictive value in predicting MACCE within 12 months after STEMI and NSTEMI.
Study context
- Population
- Patients with STEMI and NSTEMI hospitalized between 2013 and 2021, with and without T2D
- Participants
- 1,706 patients
- Exposure
- Patients with T2D vs without T2D; prognostic value of TyG index, TyG-BMI and metabolic score for insulin resistance (METS-IR)
- Outcome
- In-hospital death and MACCE (death from any cause, myocardial infarction (MI), stroke, revascularization)
- Follow-up
- Within 12 months
Main finding
As reported in the abstract
AUC-ROC of TyG index for in-hospital death (p < 0.001)
0.69
AUC-ROC of METS-IR for in-hospital death (p < 0.001)
0.682
AUC-ROC of TyG index for major adverse cardiac and cerebrovascular events (MACCE) (p < 0.001)
0.582
AUC-ROC of METS-IR for MACCE (p < 0.001)
0.57
Observational data: associations, not effects.
Further findings
In-hospital death
P = 0.1
MACCE · 12 months
P < 0.001
- In-hospital death — In-hospital deaths, total
- 58
- MACCE — MACCE in total population
- 18.9%
- TyG index, TyG-BMI and METS-IR · significantly higher with T2DM
- P < 0.001
Original publication
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