The protective role of SGLT2 inhibitors on aortic aneurysm mediated by oxidative stress and inflammation in type 2 diabetes mellitus
Main finding · Aortic aneurysmResult — go to the resultHazard ratio 0.91 95% CI 0.89–0.98Authors' conclusion
Our study suggested that patients using SGLT2i may have a lower risk of aortic aneurysm, and this effect could potentially be mediated by inflammation and oxidative stress. Further mechanistic and prospective studies are required to verify this association.
Study context
- Population
- Patients with T2D, First Affiliated Hospital of Zhengzhou University, July 2017 to January 2023
- Participants
- 4,964 patients
- Exposure
- SGLT2 inhibitor (SGLT2i) use vs no SGLT2i use
- SGLT2in = 1,942
- NonSGLT2in = 3,022reference
- Outcome
- Risk of aortic aneurysm
Methodological detailssingle-centre, mediation analysis, sensitivity analysis
- Single-centre
- Mediation analysis
- Sensitivity analysis
Main finding
Aortic aneurysm
Hazard ratio
0.91
95% CI 0.89–0.98
P = 0.001
SGLT2ivs NonSGLT2i
HR 0.91 (95% CI 0.89–0.98); P = 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Aortic aneurysm, dapagliflozin
| HR (95% CI) | P value | ||
|---|---|---|---|
| Dapagliflozin | 0.84 (0.80–0.95) | P = 0.011 | |
| 0.512Hazard ratio (log scale) |
Aortic aneurysm, subgroups
- SGLT2i use lowered the risk of aortic aneurysm in some subgroups of T2D patients
Sensitivity analysis
- Sensitivity analysis demonstrated robustness of the results
Mediation of SGLT2i–aortic aneurysm association
- Mediation proportion, CRP
- 13.35%
- Mediation proportion, lymphocytes
- 8.83%
- Mediation proportion, neutrophils
- 9.67%
- Mediation proportion, uric acid
- 31.17%
Original publication
The protective role of SGLT2 inhibitors on aortic aneurysm mediated by oxidative stress and inflammation in type 2 diabetes mellitus. Cardiovasc Diabetol. Published 7 February 2025. doi:10.
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