Type 1 diabetes

Increased risk of dementia in Type 1 diabetes: A systematic review with meta-analysis

Diabetes Res Clin PractPublished Systematic review and meta-analysis

Pooled result · All-cause dementiaResult — go to the resultPooled hazard ratio 1.50 95 % CI 1.25–1.80

Authors' conclusion

This review provides robust evidence linking Type 1 diabetes to increased dementia risk

Study context

Population
Individuals with T1D vs controls; studies in CINAHL, EMBASE, MEDLINE, PSYCINFO and Web of Science, published in English19 studies
Comparison
T1D vs controls
Outcome
All-cause dementia risk
Methodological detailsQuality assessed with QUADAS-2
  • Quality assessed with QUADAS-2

Pooled result

All-cause dementia

Pooled hazard ratio

1.50

95 % CI 1.25–1.80

P < 0.001

T1Dvs Controls
pooled HR 1.50 (95 % CI 1.25–1.80); P < 0.001

As reported in the abstract

Increased risk of dementia with T1D vs controls
50 %

Original publication

Increased risk of dementia in Type 1 diabetes: A systematic review with meta-analysis. Diabetes Res Clin Pract. Published 16 February 2025. doi:10.1016/j.diabres.2025.112043

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