Early increase in carotid intima-media thickness in women with childhood-onset type 1 diabetes compared with healthy peers: the Norwegian Atherosclerosis and Childhood Diabetes study
Main finding · Mean cIMT increase in young women, T1D vs controlsResult — go to the result∆ 0.019 mm CI 0.001–0.035Authors' conclusion
Young women with childhood-onset type 1 diabetes of relatively short diabetes duration had a higher mean cIMT over a 10-year period compared with their healthy female controls, with values similar to males.
Study context
- Population
- Individuals with childhood-onset T1D and healthy controls; Norwegian Childhood Diabetes Registry data for traditional risk factors
- Participants
- 329 vs 173
- Exposure
- Childhood-onset T1D vs healthy controls
- Type 1 diabetesn = 329
- Controlsn = 173reference
- Outcome
- Carotid intima-media thickness (cIMT)
- Follow-up
- Baseline, 5 and 10 years
Methodological detailsfollow-up every fifth year
- Follow-up every fifth year
Main finding
As reported in the abstract
Mean cIMT increase in young women, T1D vs controls · 10-year period
∆
0.019 mm
CI 0.001–0.035
P = 0.035
Observational data: associations, not effects.
Further findings
Characteristics of T1D group at 10-year follow-up (baseline)
- Mean age, years (baseline 13.7±2.8)
- 24.2±2.9
- Diabetes duration, years (baseline 5.4±3.3)
- 15.6±3.4
- HbA1c (baseline 8.4±3.4% (68±13 mmol/mol))
- 8.2±3.6% (66±16 mmol/mol)
Risk factors vs controls, by sex
- Women with T1D: significantly higher mean weight, BMI, waist circumference, diastolic blood pressure (DBP), LDL-C and apolipoprotein B
- Men with T1D: significantly higher mean DBP and urinary albumin-creatinine ratio
Association of carotid intima-media thickness (cIMT) change with HbA1c or LDL-C burden
- Mean cIMT change not associated with long-term HbA1c or LDL-C burden in childhood and adolescence
Original publication
Early increase in carotid intima-media thickness in women with childhood-onset type 1 diabetes compared with healthy peers: the Norwegian Atherosclerosis and Childhood Diabetes study. BMJ Open Diabetes Res Care. Published 16 February 2025. doi:10.
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