Preclinical carotid atherosclerosis is independently associated with cardiovascular events and mortality in type 1 diabetes
Authors' conclusion
Preclinical carotid atherosclerosis in adults with T1D was independently associated with an increased risk of cardiovascular events and mortality.
Study context
- Population
- Adults with T1D in primary prevention in a cardiovascular risk assessment program with carotid US (age ≥ 40 years, DKD, or T1D duration ≥ 10 years plus ≥1 additional CV risk factor); mean age 48.5 years, T1D duration 27 years, 51.9% males
- Participants
- 701 adults
- Exposure
- Carotid plaque presence/burden vs no plaque
- Outcome
- First cardiovascular event (CVE)
- Follow-up
- Mean 5.85 years
Main finding
As reported in the abstract
First CVE · mean 5.85 years
Each group vs no plaqueHazard ratio (95% CI)
Any plaqueunadjusted
3.14(1.69–5.84)
High plaque burdenmultivariable adjusted for demographic, metabolic and microvascular factors
3.38(1.37–8.38)
- Cardiovascular events (CVE) during follow-up (18 coronary artery disease, 14 peripheral artery disease, 6 stroke, 3 HF, 4 deaths)
- 45
- Event-free survival declined progressively with increasing plaque burden
- log-rank p < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| Composite of CVE plus all-cause mortalityAny plaquevs No plaqueUnadjusted | 3.07 (1.71–5.51) | |
| Composite of CVE plus all-cause mortalityHigh plaque burdenvs No plaqueMultivariable adjusted | 2.64 (1.13–6.21) | |
| 0.10.31310Hazard ratio (log scale) |
- Composite of CVE plus all-cause mortality — Non-cardiovascular deaths
- 5
Original publication
Preclinical carotid atherosclerosis is independently associated with cardiovascular events and mortality in type 1 diabetes. Cardiovasc Diabetol. Published 23 July 2026. doi:10.
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