Celiac disease and celiac serology in children with Type 1 Diabetes: diagnostic timing, serologic patterns, and implications for long-term management
Authors' conclusion
In conclusion, most, but not all, patients with T1DM and elevated celiac serology, eventually develop biopsy-confirmed CeD.
Study context
- Population
- Children with T1D treated at a single tertiary center (2009–2024); 136 with positive anti-TTG136 anti-TTG positive
- Participants
- 1,799 children
- Exposure
- Celiac disease (CeD) vs Persistent seropositivity vs Single borderline
- CeDn = 113
- Persistent seropositivityn = 15
- Single borderlinen = 8reference
- Outcome
- Temporal relationship between T1D and CeD diagnoses, and long-term natural history of celiac serology and CeD diagnosis
Methodological detailssingle tertiary center
- Single tertiary center
Main finding
As reported in the abstract
Timing of CeD diagnosis relative to T1D
CeD diagnosed after T1D
81.4%
CeD diagnosed prior to T1D
18.6%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| CeD diagnosed prior vs after T1D: GI symptoms, EMA positivity, glycaemic control | P < 0.05 |
| HbA1c at follow-upCeD vs Single borderline · significantly higher with CeD | P < 0.01 |
- CeD diagnosed prior vs after T1D: GI symptoms, EMA positivity, glycaemic control: more GI symptoms, higher EMA positivity, poorer glycaemic control with CeD prior to T1D
Original publication
Celiac disease and celiac serology in children with Type 1 Diabetes: diagnostic timing, serologic patterns, and implications for long-term management. Pediatr Diabetes. Published 23 July 2026. doi:10.
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